Reagan was on the run from his enemies from the start.
And it was a run that took the lives of nearly 2,000 people and a huge political cost to his party.
Here are the stories of those who died or disappeared during that time.
Richard C. Kohn: The conservative journalist and commentator died in 1986 after being shot in the head in a bar fight in New York City.
He was the first of the Reagan “crusaders” to be assassinated.
He died at age 78 in New Jersey.
Michael L. Shumway: The veteran New Jersey cop who was shot and killed in the back in 1983, his killing sparking a political firestorm that left the GOP leader in office for just one term.
Tom Brokaw: The former ABC News president and Fox News host died in 1992 after being hit by a car while riding his motorcycle in his home state of New Jersey, according to his family.
Richard Posner: The prominent conservative columnist who had a political career that spanned more than 30 years died in 1990 after being found in a hotel room in the Hamptons.
Bob Woodward: The journalist and Pulitzer Prize winner who died in 2010 at age 90, after having a stroke.
John Nichols: The legendary Watergate reporter and Watergate conspirator who was found dead in his New York apartment after his death in 1973.
Robert F. Kennedy Jr.: The former president’s son who was killed in Dallas in 1968.
Ronald Reagan: The Republican leader who was assassinated in 1981.
Donald Rumsfeld: The defense secretary, former vice president and U.S. secretary of defense who was fatally wounded in his house by a gunman at the Republican National Convention in 1980.
Roger Stone: The anti-war activist and Trump supporter who was the target of the FBI’s wiretapping investigation, who died at a nursing home in Washington, D.C. 11.
Joe Lieberman: The U.K. politician who served as governor of Connecticut and served as a senior aide to former President Bill Clinton and was the subject of a leaked memo that suggested the Clintons may have been involved in a sexual assault.
Ted Kennedy: The father of slain U.N. Ambassador John F. Kenney died in 2002.
Mark Felt: The retired senior intelligence analyst and whistleblower who worked with President George W. Bush on the Iran-Contra scandal died in a plane crash in 2008.
Tom DeLay: The Texas congressman and staunch conservative who had been working for Republicans in Congress, died in 2007 in a helicopter crash after he was shot by a sniper in his Texas ranch.
Jim Baker: The Massachusetts senator who became House speaker in 1993 and served in the House of Representatives for the first eight years of President George H.W. Bush’s administration.
Jimmie Bush: The governor of Florida and vice president in the Reagan administration, who was murdered by a man with a shotgun in 2003 after he and another member of his family were in a house in Lake Charles, Louisiana, when a gunman opened fire.
Mark Foley: The chief executive of the Tampa Bay Rays baseball team who died from a gunshot wound to the head.
Richard Lugar: The Indiana senator who was defeated by the Democratic presidential nominee in 1988, leaving him unable to seek reelection for the Senate in 1992.
Paul G. Allen: The senior aide who helped Vice President George HW Bush win the 1988 election, and who served in his Cabinet.
Mike Mansfield: The Army officer who served three tours of duty in Iraq and was wounded in an attack by the Taliban in 2006.
Michael Milken: The billionaire financier who founded the investment bank Morgan Stanley, who left the firm in 2002 after losing $2 billion on a derivatives bet.
Michael Steele: The director of the CIA, who resigned in 2004 after the agency released a report concluding that Iran was developing nuclear weapons.
David Plouffe: The president of the New York University School of Law, who had worked for President George Bush, was killed at age 57 in an auto accident in a suburban Chicago suburb in 2008 after he lost his wife, daughter, son-in-law and two grandchildren.
Richard Nixon: The Democratic president who was impeached in 1974 for perjury and obstruction of justice for his role in the Watergate scandal.
Mike Deaver: The Washington Post columnist who became one of the first conservative commentators to voice support for the Iraq War in 1991 and later became a key ally of the GOP, who in the late 1990s became a Republican national committeeman and served two terms in Congress.
Jim Crow laws: The Supreme Court decision that effectively legalized segregation in the South, and was a major factor in the rise of the civil rights movement.
James Carville: The liberal former MSNBC